|
KMID : 0931320120120030171
|
|
대한상부위장관.헬리코박터학회지
2012 Volume.12 No. 3 p.171 ~ p.177
|
|
|
The Clinical Significance of Specialized Intestinal Metaplasia in the Diagnosis of Barrett’s Esophagus: Nationwide Prospective Multicenter Study
|
|
Park Hyun-Kyung
Kim Na-Young
Lee Byoung-Hwan
Kim Jin-Il
Lee So-Young
Cha Hyun-Min
Park Soo-Heon
Kim Hye-Rang
Park So-Hyun
Lee Sang-Woo
Park Jong-Jae
Shim Ki-Nam
Kim Seong-Eun
Hong Su-Jin
Chung Il-Kwun
Baik Gwang-Ho
Kim Hyun-Soo
Kim Sung-Kook
Sung Jae-Kyu
Seo Geom-Seog
Jee Sam-Ryong
Moon Jeong-Seop
Cho Mee-Yon
Kim Jae-Woo
Park Seon-Mee
Nah Byung-Kyu
Chung Moon-Gi
Nam Su-Youn
Seo Kang-Seok
Ko Byung-Sung
Jo Yun-Ju
Jang Jae-Young
Kim Byeong-Gwan
Kim Ji-Won
Park Kyung-Sik
Park Hyun-Shin
Kim Young-Sun
Lim Seon-Hee
Kim Chung-Hyeon
Park Min-Jung
Yim Jeong-Yoon
Cho Kyung-Ran
Kim Dong-Hee
Park Seon-Ja
Song Geun-Am
Kim Hyun-Jin
Kim Sang-Wook
Im Euyi-Hyeog
Lee Kyoung-Soo
Hyun Dong-Hyo
Kim Hyun-Young
Kim Sun-Mi
Shin Jeong-Eun
Park Chan-Kuk
Yang Chang-Heon
Chung In-Sik
Jung Hyun-Chae
|
|
|
Abstract
|
|
|
Background/Aims: The meaning of specialized intestinal metaplasia (SIM) in the diagnosis of Barrett’s esophagus (BE) is not clear. This study was designed to determine the clinical significance of SIM in the diagnosis of Barrett’s esophagus.
Materials and Methods: Biopsies were taken from 601 subjects with endoscopically suspected columnar-lined esophagus. Under light microscopy with Alcian-blue stain, SIM was identified. Demographic characteristics, gastroesophageal (GE) reflux symptoms and endoscopic findings were compared between the SIM-present group and the SIM-absent group.
Results: Among 601 subjects, 184 (30.6%) were confirmed by pathology to have SIM. Age over 40 years (P＜0.001) and a medication history of proton pump inhibitor or H2 blocker were found more frequently in the SIM-present group (P=0.01) than in the SIM-absent group. Any of 7 GE reflux symptoms (heartburn, acid regurgitation, chest pain, hoarseness, globus sensation, cough and epigastric soreness) were more frequent in the SIM-present group than SIM-absent group (P＜0.001). Specifically, heartburn, chest pain and cough were significantly more common in the SIM-present group. There was no clinically significant difference associated with endoscopic findings or other clinical characteristics.
Conclusions: When subjects with endoscopically suspected BE are analyzed based on the presence or absence of SIM, the SIM-present group was significantly associated with GE reflux symptoms suggestive of frequent GE reflux. However, the presence of SIM did not correlate with endoscopic findings.
|
|
|
KEYWORD
|
|
|
Barrett esophagus, Metaplasia, Gastroesophageal reflux
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|